PENGARUH EKSTRAK BUAH NAGA MERAH TERHADAP KADAR MDA TIKUS YANG DIBERI PAPARAN ASAP ROKOK

Novera Herdiani, Endah Budi Permana Putri

Abstract


Smoking becomes the main factor that caused cardiovascular in the world lead to the highest death. Cigarette smoke contains free radicals which are harmful to the body. Once there are too many free radicals exist in the body, the antioxidant could not neutralize it. Red dragon fruit is known as source of antioxidant. This study aimed to analyze the effect of red dragon fruit to the decrease MDA level in rat which has exposed by cigarette smoke. Total samples are 24 male rats and divided into four groups namely: negative control (KN), positive control (KP), treatment with red dragon fruit extract as much as 7.2 g/200 g BW (P1), and treatment with red dragon fruit extract as much as 10.8 g/200 BW (P2). Negative control group was treated with standard feed. Positive control group was treated with standard feed and exposed with 2 cigarette smoke per day. Treatment groups were treated with standard feed and red dragon fruit extract in the morning and after exposure 2 cigarette smoke. This study has observed for 21 days. In the end of the treatment, blood serum was used to analyze smoke the specify of MDA grade. The result of MDA level was analyzed with One Way ANOVA and followed by HSD test at level of 5%. The result showed that MDA level in positive group reveals differences with P1 group as 0.011 < 0.05. Furthermore, MDA level on positive control showed slightly difference with P2 group as 0.005 < 0.05. We concluded that red dragon fruit extract treatment at 7.2 g/200 g BW, and 10.8 g/200 BW significantly decreased MDA levels in rat which are exposed with cigarette smoke.

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DOI: https://doi.org/10.47007/ijobb.v2i1.21

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