Response of human umbilical cord mesenchymal stem proliferation during exposure to curcumin extract variations in dose and time

Abstract

Mesenchymal stem cells can be isolated from various body tissues, including umbilical cord tissue or mesenchymal stem cells (hUC-MSC). hUC-MSC cells have a role as immunomodulators and have low immunogenicity. hUC-MSC cell culture is essential to optimize its role in treating various diseases. Stimulation of cell proliferation and differentiation from natural active compounds is essential as a substitute for synthetic growth factors, which are expensive and limited. Curcumin is an active compound from the Curcuma longa L. plant with potential in various molecular signaling pathways. Proliferation of hUC-MSC cells is needed to support successful therapy in degenerative or infectious diseases. This study proves that curcumin at a concentration dose of 0.5 µM and one µM significantly increases the proliferation of hUC-MSC cultures on exposure to three days and seven days. Using curcumin as a culture supplement to stimulate the growth and proliferation of hUC-MSC culture cells in vitro is essential as a substitute for synthetic growth factors.