Efektivitas Ciprofloksasin pada Infeksi Pseudomonas aeruginosa yang Disertai Koinfeksi Staphylococcus aureus Secara In Vitro

Abstract

Background: Burn wounds are frequently accompanied by opportunistic bacterial infections, such as Pseudomonas aeruginosa and Staphylococcus aureus, which form biofilms and contribute to chronic infections. Antibiotic resistance complicates therapy, particularly in polymicrobial infections.

Objective: This study aimed to evaluate the effectiveness of ciprofloxacin against P. aeruginosa in single and co-infection with S. aureus under in vitro conditions.

Methods: An experimental study was conducted using the Kirby-Bauer disk diffusion method with four treatment groups: single infection of P. aeruginosa with ciprofloxacin (K1), co-infection of P. aeruginosa + S. aureus with ciprofloxacin (K2), single infection without antibiotic (K3), and co-infection without antibiotic (K4). Data were analyzed descriptively and statistically using the Mann–Whitney U test.

Results: The inhibition zone diameter of ciprofloxacin in K1 was 29.76 mm and 30.67 mm in K2. There was no significant difference between the two groups (p = 0.100).

Conclusion: Ciprofloxacin remains effective against P. aeruginosa in both single and co-infection conditions with S. aureus. The presence of S. aureus does not significantly reduce ciprofloxacin efficacy.