Titta Novianti, Vetnizah Juniantito, Ahmad Aulia Jusuf, Evy Ayu Arida, Mohamad Sadikin, Sri Widia A. Jusman


The oxygen need is very important in tissue regeneration process for the sustainability of metabolic process. The high activity of cells and tissues during regeneration requires high energy therefore oxygen demand is very high. Cytoglobin (Cygb) is a protein that plays a role to diffuse oxygen to mitochondria. Cygb is a molecule that has a high affinity to oxygen and expressed during hypoxic conditions, when the tissue lacks oxygen. The tissue in regeneration process experiences at hypoxia state, Cygb protein expression have an important role during the tissue regeneration process. The Spearman correlation test results the strong correlation between the expression of Cygb protein of immunoratio test in immunohistochemical staining with the growth of epidermal thickness of tissue (r = 0.67; p <0.05). The results of correlation test between Cygb protein expression with the growth of dermis thickness showed moderate correlation properties (r = 0.406; p <0.05).

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Indonesian Journal of Biotechnology and Biodiversity

ISSN 2581-0014

published by:

Department of Biotechnology, Faculty of Health, Universitas Esa Unggul

Jalan Arjuna Utara No. 9, Kebon Jeruk, Jakarta Barat