Effect of Various Doses of Kenikir Flower Crown Extract (Targetes erecta L.) on Reducing Blood Glucose Levels in Rats

Abstract

Diabetes mellitus is a metabolic disease caused by the body experiencing disturbances in controlling sugar levels, and the insulin hormone is impaired or does not meet the requirements. The purpose of this study was to analyze the effect of various concentrations of extracts of the crown of kenikir flower (Tagetes erecta L.) maceration method on decreasing blood glucose levels in white rats (Rattus norvegicus). The research approach used is a quantitative approach. Type of Research True Experimental Research, with the design of The Pre Test Post Test Control Group Design. Provision of kenikir flower crown extract (Tagetes erecta L.) using the maceration method with the help of n-hexane as solvent. This study used 5 treatment groups, namely a negative control group (alloxan), a positive control group (glibenclamide), an extract dose of 25 mg/kgBW, an extract dose of 50 mg/kgBW, and an extract 70 mg/kgBW. Blood glucose levels were measured on day 1 (three days after induction) and day 24 (after treatment). The conclusion of this study was that a dose of 25 mg/kgBW gave the greatest decrease in blood glucose levels with a percentage value of 70% compared to the treatment group with a dose of kenikir flower crown extract.